





Nexirozova
Pharmaceutical
Product Details:
- Active: Rosuvastatin
- Pack of 14 Tablet
- Concentration: 5mg , 10mg , 20mg
- Speciality: All Specialities, Endocrinology & Metabolic, Cardiovascular
Brand Name: Nexirozova Tablet.
Composition:
Each Nexirozova 20mg Film tablet contains: Rosuvastatin .............................................. 20 mg
Each Nexirozova 10mg Film tablet contains: Rosuvastatin ............................................... 10 mg
Each Nexirozova 5mg Film tablet contains: Rosuvastatin .................................................. 5 mg
Therapeutic Indications:
Dosage and Administration:
○ The recommended start dose is 5 or 10 mg orally once daily in both statin naïve or patients switched from another HMG CoA reductase inhibitor. who do not achieve their treatment goal on 20 mg, and in whom routine follow-up will be performed. Specialist supervision is recommended when the 40 mg dose is initiated.
○ In the cardiovascular events risk reduction study, the dose used was 20 mg daily
Contraindications:
○ moderate renal impairment (creatinine clearance < 60 ml/min)
○ Hypothyroidism
○ personal or family history of hereditary muscular disorders
○ previous history of muscular toxicity with another HMG-CoA reductase inhibitor or fibrate
○ alcohol abuse
○ situations where an increase in plasma levels may occur
○ Asian patients
○ concomitant use of fibrates
Warnings and precautions:
Undesirable Effects:
Pharmacological Properties:
Nexirozova is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action of rosuvastatin is the liver, the target organ for cholesterol lowering.
Rosuvastatin increases the number of hepatic LDL receptors on the cell surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles belong to the proton pump inhibitor group is a medication that reduces stomach acid
Packaging:
Nexirozova 20mg Tables; box containing 2 blisters of 7 tablets each.
Nexirozova 10mg Tables; box containing 2 blisters of 7 tablets each.
Nexirozova 5mg Tables; box containing 2 blisters of 7 tablets each.
36 Al Sheikh Mohammed Al Nadi St., Off Mostafa El Nahaas St. 6th District. Nasr City, Cairo, Egypt.